The provider of product and services to lab and production customers said the regional distribution center will serve customers in Texas, Oklahoma, Arkansas and Louisiana.
Avantor acquired VWR for $6.4bn earlier this year.
"The opening of this facility marks a joyous milestone in VWR's history, especially for those employees here in Texas who have been personally involved in conceptualizing and shaping this new location," said Brian Magerkurth, VWR's VP of supply chain operations.
It is one of 10 VWR distribution facilities in North America and will offer customer-focused stock assortment.
"The new facility in Missouri City offers more than triple the storage capacity of our former Sugar Land location, providing our local customers with faster access to more products," said Mark McLoughlin, VWR's SVP and president, Americas lab and distribution services.
VWR opened a 226,000 sq. ft. chemical manufacturing site in Ohio last year.
The firm has a manufacturing facility in Solon which supports customers who produce various kits and reagents for food and beverage testing.
It is also a contract manufacturer for firms who have developed molecular based technologies used in foodborne pathogen testing.