Gene and grape antioxidant slice obesity away?

Related tags Obesity

Progress towards tackling the obesity epidemic could come from a
new study which has found that a compound commonly found in red
wine boosts the activity of an identified gene which cuts the
growth of new fat cells.

Scientists from Oregon State University, the Massachusetts Institute of Technology and the University of Ottawa claim the SIRT1 gene can not only cut the growth of fat cells, but also increase the metabolism or use of fat in existing fat cells, an activity helped by resveratrol, a polyphenol and antioxidant found at high levels in grape skins.

Rising figures for obesity from the World Health Organisation (WHO) show that globally there are more than 1 billion overweight adults, and at least 300 million of them are clinically obese. Obesity and overweight pose a major risk for chronic diseases, including type 2 diabetes, cardiovascular disease, raised blood pressur, strokes, and certain forms of cancer.

"The key causes are increased consumption of energy-dense foods high in saturated fats and sugars, and reduced physical activity,"​ says WHO.

SIRT1 is the topic of considerable recent research, and other studies have also shown that its activity level can be significantly increased by the presence of a compound found in red wine.

The new research, recently published in the journal Nature​, may help explain why moderate consumption of red wine appears to reduce deaths from heart disease, as has been suggested by some demographic studies.

The study used mice as a research model, and a remaining challenge will be to see if the same results are observed in a higher vertebrate model, including humans, say the researchers.

"When cells were exposed to resveratrol, our studies showed a pretty dramatic reduction in the conversion to fat cells and a lesser but still significant increase in the mobilisation of existing fat, or the rate at which the cells metabolised stored fat,"​ said Mark Leid, a professor of pharmacology in the OSU College of Pharmacy.

"This clearly could be one of the explanations for the health benefits that some researchers believe can be linked to moderate red wine consumption,"​ added the scientist.

They say that a range of studies have demonstrated that caloric restriction is one of the few proven methods to delay aging, improve cardiovascular health and extend mammalian lifespan.

Research done with yeast has shown that a gene called SIR2 tends to promote longevity, and that yeast cells die prematurely if this gene is deleted, Leid said.

Previous studies have shown that resveratrol can increase the activity of SIR2 and increase the lifespan of yeast cells up to 70 per cent. And it has also been found that SIRT1, a gene found in both mice and humans, has essentially the same function as SIR2 and the same reaction to stimulus by resveratrol.

In trying to determine the molecular basis for this genetic link to longevity, the new study found that SIRT1 increases the use of fat and reduces the formation of new fat cells - apparently it represses one or more fat-regulating proteins and other genes that drive fat storage following calorie restriction.

This may have been an evolutionary adaptation for the body to sense short term famine and counter it by increasing the burning of stored body fat, researchers say.

The increased activity of SIRT1 in the presence of resveratrol is clearly of interest, the researchers said, but added that it is too early to be certain of its effects in humans.

"It would be very premature to suggest that supplements of resveratrol would have any benefits, because this compound oxidises very quickly and easily loses its metabolic effectiveness,"​ said Leid. "Because of that we have a hard time even studying it in a laboratory setting. But we do know that red wine has fairly high levels of the compound, and this study would suggest at least one mechanism for possible health benefits of red wine. It may help prevent fat development and storage."

Resveratrol is found in the skins of grapes, and its concentration in wine is a reflection of the time the skins are present during the fermentation process - because of that, the levels are much higher in red wine than in white wine or other products. Other sources of the compound include mulberries, peanuts, and some other plants.

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