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Fatty diet may impact metabolism through circadian rhythms, say researchers

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By Nathan Gray+

08-Jan-2014

Fatty diet may impact metabolism through circadian rhythms, say researchers

Consumption of a high-fat diet can affect metabolism by effectively reprogramming the circadian 'clock' in our liver, according to new research.

The study, published in Cell, used high-throughput profiling of the liver metabolome and transcriptome to test the effects of a high-fat dietary challenge on metabolism - finding that the high-fat diet (HFD) challenge altered the molecular mechanism that control the internal body clock which regulates metabolic functions in the liver.

Led by Professor Paolo Sassone-Corsi from the University of California-Irvine, the team suggested that such disruption of these circadian rhythms could contribute to metabolic distress and diseases including diabetes, obesity and high blood pressure.

"HFD induces transcriptional reprogramming within the clock that reorganizes the relationships between the circadian transcriptome and the metabolome," wrote the research team.

"Nutrients have powerful effects on the cellular clock, revealing its intrinsic plasticity," they explained. "These effects consist not only of the abrogation of pre-existing rhythms but the genesis of rhythms where they do not normally exist. This induction is rapid and does not require the onset of obesity."

Reversing the rhythm?

In addition to finding that a high-fat diet has a negative impact on metabolism and circadian rhythm, Sassone-Corsi and his team also found that returning to a balanced, low-fat diet normalised the rhythms.

"The reversible nature of these effects gives hope for novel nutritional and pharmaceutical strategies," commented the research team.

Study details

The team reported that the high-fat diet reprograms the liver clock through two main mechanisms: one which blocks normal cycles by impeding the clock regulator genes known as CLOCK:BMAL1, while another initiates a new program of oscillations by activating genes that normally do not oscillate. This occurs principally through a factor called PPAR-gamma, the team said.

Sassone-Corsi commented that it is noteworthy that this reprogramming takes place independently of obesity; rather, it's solely dependent upon caloric intake – showing the remarkable adaptability of the circadian clock.

The team now plan to extend their research to assess the effects of high-fat diet on other body tissues and functions, including muscle, fat, the brain and blood plasma.

Source: Cell
Volume 155, Issue 7 , Pages 1464–1478, doi: 10.1016/j.cell.2013.11.034
"Reprogramming of the Circadian Clock by Nutritional Challenge"
Authors: Kristin L. Eckel-Mahan, Vishal R. Patel, Sara de Mateo, et al

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4 comments (Comments are now closed)

lazy study

What a careless study! What kinds of fats are we talking about? Processed fats? Trans fats? PUFAS? MUFAS? Unprocessed/natural fats? Clearly the type of fat will affect the way it is processed in the body and thus the results of a study such as this.

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Posted by Rachael
17 January 2014 | 02h22

high fat diet may be innocuos

no food per se is detrimentalto health but the excess eaten any one time is that promotes the deseases mentioned

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Posted by Gustavo Cordova
15 January 2014 | 18h42

no disclosure of fat source

Different fats give different results. Was it a trans fat? animal fat,nut corn, soy etc? It should have been studied with at least 2 different fats to see how they differ.

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Posted by roger parent
11 January 2014 | 07h53

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