High-fat diet could cause brain changes that lead to anxiety and depression: Mouse data

By Nathan Gray contact

- Last updated on GMT

High-fat diet could cause brain changes that lead to anxiety and depression: Mouse data

Related tags: High fat diet, Nutrition, Blood sugar

Increased body weight and high blood sugar as a result of consuming a high-fat diet may lead to anxiety and depressive symptoms and measurable changes in the brain, say researchers.

The mouse study, published in the British Journal of Pharmacology, ​investigated the link between diet, diabetes and depression by testing the influence of type 2 diabetes on emotionality.

Led by senior author, Dr Bruno Guiard, the research team reported that increased body weight, hyperglycaemia and impaired glucose tolerance in response to a high fat diet (HFD) are correlated with anxiogenic/depressive-like symptoms in mice, while the beneficial effects of an antidepressant were also found to be blunted in mice fed a high-fat diet.

“On the contrary, HFD withdrawal completely reversed metabolic impairments and positively impacted anxious symptoms, although some behavioural anomalies persisted,”​ said the team – adding that the data provides “clear-cut evidence that both pathologies are finely correlated and associated with impaired hippocampal serotonergic neurotransmission.”

Guiard said the evidence that removing a HFD and reversing the metabolic impacts of diabetes can also lead to positive changes on anxiety and depression reinforces an existing idea that the normalisation of metabolic parameters may give a better chance of achieving remission for people with depression, and particularly in depressed patients with type 2 diabetes.

The results set the tone for future investigations on potential mechanisms that may link metabolic and psychiatric disorders.

Related topics: Science, Fats & oils

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9 comments

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it is a pity that science of nutrition was so wrongly reported

Posted by Dr Pelouze,

1/ figures 3,4 and 5 of the paper are not available...
2/ reference: http://onlinelibrary.wiley.com/doi/10.1111/bph.13343/abstract
3/ The HFD in mice is a model to study GLUCOSE intolerance!
http://diabetes.diabetesjournals.org/content/53/suppl_3/S215.full
4/it is not a matter of specific fatty acids:
Also, in our own study, we were not able to detect significant correlations between the saturation level of free fatty acids and insulin action as estimated from whole-body glucose disposal after an insulin challenge (Figure 2).
http://onlinelibrary.wiley.com/doi/10.1038/oby.2007.608/full
Conclusion:
as usual those exp studies on rodents should be reported with extreme caution about any translational knowledge applicable to humans. issues about carbs and fats are complex and extremely controversial so a more balanced approach should be to report also other studies by instance this one/
"Results: Higher TC, higher HDL-C, and lower triglycerides were associated with higher age 70 cognitive scores in most cognitive domains. These relationships were no longer significant after covarying for childhood IQ, with the exception a markedly attenuated association between TC and processing speed, and triglycerides and age 70 IQ. In the fully adjusted model, all conventionally significant (p < 0.05) effects were removed. Childhood IQ predicted statin use in old age. Statin users had lower g, processing speed, and verbal ability scores at age 70 years after covarying for childhood IQ, but significance was lost after adjusting for TC levels.

Conclusions: These results suggest that serum cholesterol and cognitive function are associated in older age via the lifelong stable trait of intelligence. Potential mechanisms, including lifestyle factors, are discussed."
http://dysnutrition.blogspot.fr/2015/10/cholesterol-and-cognitive-function.html

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A mice study about high blood sugar

Posted by Dr Pelouze,

"Increased body weight and high blood sugar resulting of a high fat diet"
Are you kidding in incriminating fat?

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fat mice fed on FAT - who ARE you kidding?

Posted by Steve Pickering,

Bad science and bad journalism. Showing fat mice and talking about fat diet is both an anachronism and misrepresentation. Carbohydrates and refined sugars cause obesity, not fat. Get real!

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